Mansions of Madness Second Edition is a fully cooperative board game of horror and mystery for one to five players that takes place in the same universe as Eldritch Horror and Elder Sign. Explore the veiled and misty streets of Innsmouth and stumble through the haunted corridors of Arkham's cursed mansions as you search for answers and respite. Eight brave investigators stand ready to confront four scenarios of fear and mystery, collecting weapons, tools, and information, solving complex puzzles, and fighting monsters, insanity, and death. Open the door and step inside these hair-raising Mansions of Madness Second Edition. It will take more than just survival to conquer the evils terrorizing this town.

The gameplay of Mansions of Madness Second Edition is modeled after that of the first edition, however the game's companion app and minor changes to the game system make the experience distinctly different. In the asymmetrical first edition, one player had to take on the Keeper role, controlling the monsters and mythos. In this edition, the app takes over that function, spawning creatures, generating events, and even randomizing the game board to increase the mystery and anticipation of every round. Additionally, because there is no need for a Keeper, Mansions of Madness Second Edition can be played as a single-player game.